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Symptoms of Multisystemic Disease

If a thorough diagnosis results in clear answers as to the cause of a patient’s complaints, no further research is necessary. For all other patients with unclear causes or unclear (idiopathic) diagnoses, we strongly recommend that you also consider the possibility of a chronic infection.


  • Conditions of exhaustion (chronic fatigue syndrome-CFS):
  • “Wandering” muscle and joint pain
  • Intermittent aches and pains
  • Neuropathic complaints with no clear source
  • Unclear (poly)neuropathies
  • Atypical forms of multiple sclerosis (MS), MS-like symptoms, Parkinson-like syndromes
  • Fibromyalgia
  • Some autoimmune diseases (e.g. seronegative rheumatoid arthritis, RA)
  • Unclear psychiatric diseases (possibly also chronic and/or therapy-resistant depression)


In addition to Lyme disease, there are other tick-borne diseases and it is not unusual for a patient to have more than one infection.


The central question is:

Why does the patient display these symptoms? It is important to discover the cause of these symptoms, both for Lyme disease therapy and also for the patient’s well-being.

This is especially important for those who cannot be helped by psychologists and psychiatrists, who are considered to be “out of therapy” and for whom no psychosomatic disorder is found.

When a disease is in its chronic (late form) stage, it will often present itself differently than when it is in its acute (early form) stage. This is the case when studied both clinically and in the laboratory.

A detailed thesis on the problem of symptoms can be found via this link.


Further possible organ manifestations:
  • The eye
  • The heart
  • The ENT area


As we’ve already mentioned, different Borrelia strains can also manifest themselves in different organ systems and thus cause different symptoms. A tick can transmit several different Borrelia strains as well as other pathogens.


Additional suggestions:

In the case of “migrating”, intermittent joint pain, clarification of e.g. Chlamydia trachom., Chlamydia pneum., Yersinia, Borrelia, mycoplasma infections.

In chronic and/or recurrent rhinitis, sinusitis, bronchitis, dry irritable cough over weeks, after exclusion of a tumorous disease, Chlamydia pneumoniae, Mycoplasma pneumoniae, Legionella, Aspergillus infections clarify. Is a seronegative rheumatoid arthritis or a seronegative borreliosis perhaps in reality a chlamydia infection, yersiniosis or a borreliosis with an undiscovered borrelia strain?

Chronic infections can also cause a partial weakening of the immune system by chronic infections.

Diabetics are a large group of patients. Do diabetics consider the known immunodeficiency and possibility of chronic infections when assessing any unclear symptoms?

What about the causes of some autoimmune diseases, allergies and endocrine (hormone metabolism) diseases?

Do we consider other infections such as Ehrlichiosis, Bartonellosis, Rickettsiosis, Neo-Ehrlichia… etc. when faced with certain symptoms and complaints.

Chronic Fatigue Syndrome (CFS) is discussed as a cause of chronic viral infections and possibly chronic bacterial infections and/or fungal infections.

Do we look for Borrelia, Chlamydia, Bartonella or other pathogens that can also cause vasculitis in (or if we suspect) a TIA or Apoplex (especially in younger patients)?

Concerning fibromyalgia: Borrelia cause neuropathic complaints. There is one study that has shown that the pain in fibromyalgia is neuropathic. Does this mean that patients with fibromyalgia could also have a Borrelia infection?